USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: COF1_HUMAN USC-OGP 2-DE database:  COF1_HUMAN COF1_HUMAN General information about the entry View entry in simple text format Entry name COF1_HUMAN Primary accession number P23528 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Cofilin-1; AltName: Full=18 kDa phosphoprotein; Short=p18; AltName: Full=Cofilin, non-muscle isoform;. Gene name Name=CFL1 Synonyms=CFL Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0260: pI=4.96; Mw=14509 PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0576: pI=5.61; Mw=18110 SPOT OGP-0578: pI=5.96; Mw=18044 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0849: pI=5.94; Mw=16532 SPOT OGP-0850: pI=5.96; Mw=16532 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1059: pI=5.93; Mw=18109 SPOT OGP-1060: pI=6.03; Mw=18109 SPOT OGP-1061: pI=6.12; Mw=18109 SPOT OGP-1068: pI=6.89; Mw=17588 SPOT OGP-1069: pI=6.99; Mw=17537 SPOT OGP-1070: pI=7.22; Mw=17384 SPOT OGP-1072: pI=7.84; Mw=17083 SPOT OGP-1073: pI=7.95; Mw=17033 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1345: pI=5.27; Mw=14950 SPOT OGP-1352: pI=8.49; Mw=13705 Cross-references UniProtKB/Swiss-Prot P23528; COF1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name COF1_HUMAN Primary accession number P23528 Secondary accession number(s) B3KUQ1 Q53Y87 Q9UCA2 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 195) Name and origin of the protein Description RecName: Full=Cofilin-1; AltName: Full=18 kDa phosphoprotein; Short=p18; AltName: Full=Cofilin, non-muscle isoform; Gene name Name=CFL1 Synonyms=CFL Encoded on Name=CFL1; Synonyms=CFL Keywords 3D-structure; Acetylation; Actin-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Nucleus; Phosphoprotein; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D00682; BAA00589.1; -; mRNA EMBL U21909; AAA64501.1; -; mRNA EMBL X95404; CAA64685.1; -; mRNA EMBL BT006846; AAP35492.1; -; mRNA EMBL AK097690; BAG53513.1; -; mRNA EMBL CH471076; EAW74449.1; -; Genomic_DNA EMBL BC011005; AAH11005.1; -; mRNA EMBL BC012265; AAH12265.1; -; mRNA EMBL BC012318; AAH12318.1; -; mRNA EMBL BC018256; AAH18256.1; -; mRNA CCDS CCDS8114.1; -; . PIR S12632; S12632; . RefSeq NP_005498.1; NM_005507.2; . UniGene Hs.170622; -; . PDB 1Q8G; NMR; -; A=1-166 PDB 1Q8X; NMR; -; A=1-166 PDB 3J0S; EM; 9.00 A; M/N/O/P/Q/R/S/T/U/V/W/X=1-166 PDB 4BEX; X-ray; 2.80 A; 1=1-166 PDB 5HVK; X-ray; 3.50 A; B/D=2-166 PDB 5L6W; X-ray; 2.53 A; C=1-166 PDBsum 1Q8G; -; . PDBsum 1Q8X; -; . PDBsum 3J0S; -; . PDBsum 4BEX; -; . PDBsum 5HVK; -; . PDBsum 5L6W; -; . ProteinModelPortal P23528; -; . SMR P23528; -; . BioGrid 107499; 148; . DIP DIP-33000N; -; . IntAct P23528; 76; . MINT MINT-4999473; -; . STRING 9606.ENSP00000309629; -; . ChEMBL CHEMBL1075129; -; . DrugBank DB04147; Lauryl Dimethylamine-N-Oxide; . iPTMnet P23528; -; . PhosphoSitePlus P23528; -; . SwissPalm P23528; -; . BioMuta CFL1; -; . DMDM 116848; -; . DOSAC-COBS-2DPAGE P23528; -; . OGP P23528; -; . REPRODUCTION-2DPAGE IPI00012011; -; . SWISS-2DPAGE P23528; -; . UCD-2DPAGE P23528; -; . EPD P23528; -; . PaxDb P23528; -; . PeptideAtlas P23528; -; . PRIDE P23528; -; . TopDownProteomics P23528; -; . DNASU 1072; -; . Ensembl ENST00000308162; ENSP00000309629; ENSG00000172757; . Ensembl ENST00000525451; ENSP00000432660; ENSG00000172757; . GeneID 1072; -; . KEGG hsa:1072; -; . CTD 1072; -; . DisGeNET 1072; -; . GeneCards CFL1; -; . H-InvDB HIX0009009; -; . HGNC HGNC:1874; CFL1; . HPA CAB033687; -; . HPA CAB037077; -; . HPA HPA053761; -; . MIM 601442; gene; . neXtProt NX_P23528; -; . OpenTargets ENSG00000172757; -; . PharmGKB PA26423; -; . eggNOG KOG1735; Eukaryota; . eggNOG ENOG41122P5; LUCA; . GeneTree ENSGT00440000033289; -; . HOGENOM HOG000039697; -; . HOVERGEN HBG000381; -; . InParanoid P23528; -; . KO K05765; -; . PhylomeDB P23528; -; . TreeFam TF328601; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation; . Reactome R-HSA-3928662; EPHB-mediated forward signaling; . Reactome R-HSA-399954; Sema3A PAK dependent Axon repulsion; . SignaLink P23528; -; . SIGNOR P23528; -; . ChiTaRS CFL1; human; . EvolutionaryTrace P23528; -; . GeneWiki Cofilin_1; -; . GenomeRNAi 1072; -; . PMAP-CutDB P23528; -; . PRO PR:P23528; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000172757; -; . ExpressionAtlas P23528; baseline and differential; . Genevisible P23528; HS; . GO GO:0015629; C:actin cytoskeleton; IEA:InterPro; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell; . GO GO:0005634; C:nucleus; TAS:UniProtKB; . GO GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell; . GO GO:0031982; C:vesicle; IDA:UniProtKB; . GO GO:0051015; F:actin filament binding; IDA:UniProtKB; . GO GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc; . GO GO:0030042; P:actin filament depolymerization; IDA:UniProtKB; . GO GO:0007010; P:cytoskeleton organization; IMP:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB; . GO GO:0044794; P:positive regulation by host of viral process; IMP:AgBase; . GO GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB; . GO GO:0061001; P:regulation of dendritic spine morphogenesis; IMP:ParkinsonsUK-UCL; . GO GO:0009615; P:response to virus; IEP:UniProtKB; . GO GO:0007266; P:Rho protein signal transduction; TAS:ProtInc; . CDD cd11286; ADF_cofilin_like; 1; . Gene3D 3.40.20.10; -; 1; . InterPro IPR002108; ADF-H; . InterPro IPR029006; ADF-H/Gelsolin-like_dom; . InterPro IPR017904; ADF/Cofilin; . InterPro IPR027234; Cofilin_1; . PANTHER PTHR11913; PTHR11913; 1; . PANTHER PTHR11913:SF37; PTHR11913:SF37; 1; . Pfam PF00241; Cofilin_ADF; 1; . PRINTS PR00006; COFILIN; . SMART SM00102; ADF; 1; . PROSITE PS51263; ADF_H; 1; .

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